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Piccirilli, Joseph A.

One or more keywords matched the following items that are connected to Piccirilli, Joseph A.

Item Type	Name
Concept	RNA, Catalytic
Academic Article	RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Academic Article	Metal ion catalysis in the Tetrahymena ribozyme reaction.
Academic Article	Three metal ions at the active site of the Tetrahymena group I ribozyme.
Academic Article	A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
Academic Article	Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article	Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns.
Academic Article	The role of the cleavage site 2'-hydroxyl in the Tetrahymena group I ribozyme reaction.
Academic Article	Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
Academic Article	Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Academic Article	Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article	Identification of an active site ligand for a group I ribozyme catalytic metal ion.
Academic Article	The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
Academic Article	A second divalent metal ion in the group II intron reaction center.
Academic Article	General acid catalysis by the hepatitis delta virus ribozyme.
Academic Article	Synthesis and biochemical application of 2'-O-methyl-3'-thioguanosine as a probe to explore group I intron catalysis.
Academic Article	Identification of catalytic metal ion ligands in ribozymes.
Academic Article	Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article	Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Academic Article	Nucleotide analogues to investigate RNA structure and function.
Academic Article	Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article	Syntheses of (2')3'-15N-amino-(2')3'-deoxyguanosine and determination of their pKa values by 15N NMR spectroscopy.
Academic Article	Biochemistry. Toward understanding self-splicing.
Academic Article	Functional identification of ligands for a catalytic metal ion in group I introns.
Academic Article	A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.
Academic Article	Thermodynamic evidence for negative charge stabilization by a catalytic metal ion within an RNA active site.
Academic Article	Tightening of active site interactions en route to the transition state revealed by single-atom substitution in the guanosine-binding site of the Tetrahymena group I ribozyme.
Academic Article	2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
Academic Article	Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment.
Academic Article	Origin of life. RNA seeks its maker.
Academic Article	Modulation of individual steps in group I intron catalysis by a peripheral metal ion.
Academic Article	Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article	Defining the catalytic metal ion interactions in the Tetrahymena ribozyme reaction.
Academic Article	Functional identification of catalytic metal ion binding sites within RNA.
Academic Article	The 2'-hydroxyl group of the guanosine nucleophile donates a functionally important hydrogen bond in the tetrahymena ribozyme reaction.
Academic Article	A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article	A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article	Origins of life: RNA made in its own mirror image.
Academic Article	Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
Academic Article	Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
Academic Article	Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.
Academic Article	Crystal structure of the Varkud satellite ribozyme.
Academic Article	An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
Academic Article	RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.
Academic Article	Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
Academic Article	Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
Academic Article	Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
Academic Article	The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design.
Academic Article	Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme.
Academic Article	Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme.
Academic Article	The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.
Academic Article	Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage.

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RNA Catalytic